Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) ke karabelo e sa tloaelehang ea letlalo eo maemong a 90% e amanang le tsamaiso ea meriana. Acute generalized exanthematous pustulosis e bonahala ka ho phatloha ha letlalo ka tšohanyetso ho hlahang ka karolelano matsatsi a mahlano ka mor'a hore meriana e qale. Ho phatloha hona ke li-pustules, ke hore ho phatloha ho honyenyane ho bofubelu bo bofubelu bo bofubelu kapa bo bofubelu ba letlalo le nang le lintho tse koahetsoeng ke maru kapa purulent (pus). Hangata maqeba a letlalo a fela ka mor'a matsatsi a 1-3 ka mor'a ho emisa meriana e khopisang.
☆ Liphethong tsa 2022 Stiftung Warentest tse tsoang Jeremane, khotsofalo ea bareki ka ModelDerm e ne e le tlase hanyane ho feta lipuisano tse lefelloang tsa telemedicine.
Maqeba a atileng a nang le erythema le pustules a hlaha ka tšohanyetso.
References
Acute generalized exanthematous pustulosis (AGEP) ke karabelo ea letlalo e tšoauoang ke makhopho a manyane a tletseng boladu bokatlaseng ba letlalo le lefubedu. Hangata ho etsahala ha motho a noa meriana e itseng, joalo ka lithibela-mafu, 'me e ata ka potlako ho pholletsa le' mele. Ka mor'a ho emisa meriana e qalang, matšoao a atisa ho fela ka mor'a libeke tse peli, hangata a siea letlalo le tšoloha. Leha hangata e se mpe ebile e se letlalo feela, linyeoe tse matla li ka aroloa hammoho le litlamorao tse ling tse matla tsa letlalo joalo ka Stevens-Johnson syndrome kapa toxic epidermal necrolysis. Kalafo ke tlhokomelo e tšehetsang haholo-holo, 'me ponelopele ea ho rarolla lefu lena hangata e ntle haholo.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Monna ea lilemo li 76 o ile a tla phaposing ea maemo a tšohanyetso hobane letlalo la hae le ne le fetohile matsatsing a mabeli a fetileng. Lingaka li ile tsa fumana mabala a khubelu 'me tsa phahamisa libaka holim'a kutu ea hae le matsoho le maoto. Ha nako e ntse e ea, liphahlo tsena li ile tsa kopana, 'me a ba le makukuno a kang lihloba libakeng tse khubelu. Liteko li bontšitse palo e phahameng ea lisele tse tšoeu tsa mali tse nang le mefuta e mengata e bitsoang li-neutrophils, le maemo a eketsehileng a C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
